hClaudin18.2/MC-38
CBPG0017
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| I. Background | |||
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Claudin18是位于細胞膜表面緊密連接的主要成分，它在維持細胞極性和屏障功能以及促進(jìn)耐酸能力方面起著(zhù)重要作用。CLDN18的第一個(gè)外顯子可以選擇性剪接，形成兩個(gè)具有高度同源氨基酸序列的不同剪接突變體(CLDN18.1和CLDN18.2)。跨膜蛋白CLDN18由兩個(gè)細胞外環(huán)、四個(gè)跨膜結構域和一個(gè)細胞質(zhì)結構域組成。 |
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| II. Introduction | |||
| Host Cell: | MC-38 | ||
| Expressed gene: | Claudin18.2 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | DMEM+10%FBS+2ug/ml puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mus musculus, mouse | ||
| Tissue: | Colon | ||
| Morphology: | Epitheloid cell | ||
| Growth Properties: | Adherent | ||
| IV. Representative Data | |||
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Figure 1. Recombinant hClaudin18.2/MC-38 stably expressing Claudin18.2. |
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