Her2 WT/BaF3
CBP73110
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產(chǎn)品描述
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| I. Introduction | |
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Cell Line Name： |
Her2 WT/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Anti-proliferation assay and PD assay |
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Freeze Medium: |
90% FBS+10% DMSO |
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Complete Culture Medium: |
RPMI-1640+10% FBS |
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Mycoplasma Status: |
Negative |
| II. Background | |
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ERBB2 (HER2), erb-b2 receptor tyrosine kinase 2, is an EGFR receptor tyrosine kinase that activates PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways, therefore regulating growth and transformation (PMID: 17471238). ERBB2 (HER2) amplification, overexpression, and activation has been implicated in several tumor types (PMID: 17471238). |
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| III. Representative Data | |
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1. WB of Her2 WT/BaF3
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2. Anti-proliferation assay |
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Figure 2. Anti-proliferation assay of two reference compounds on the Ba/F3_HER2 WT Stable Cell line. |
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